CHARLESTON, W.Va. (AP) — As a pharmaceutical company run by U.S. Sen. Joe Manchin’s daughter faces scrutiny for hiking prices on life-saving allergy injection pens, Manchin is remaining mum.

The Democratic West Virginia senator’s daughter, Heather Bresch, is CEO of Mylan, which manufactures EpiPens.

A two-dose package cost around $94 nine years ago. The cost averaged more than six times that in May.

Manchin spokesman Jonathan Kott said Wednesday the senator had no comment.

Several senators are demanding more information and requesting congressional hearings and investigations.

Sens. Amy Klobuchar of Minnesota and Richard Blumenthal of Connecticut want the Federal Trade Commission to investigate Mylan for possible antitrust violations.

Hillary Clinton, whom Manchin has endorsed for president, called the increase “outrageous.”

A Mylan statement Tuesday cited health insurance changes with higher deductible costs for many.

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WASHINGTON (AP) — Lawmakers are demanding more information on why the price of lifesaving EpiPens has skyrocketed.

EpiPens are used to ward off potentially fatal allergic reactions, and the price has surged in recent years. A two-dose package cost less than $60 nine years ago. The cost is now closer to $400.

Iowa Sen. Charles Grassley wrote the company that manufactures the devices, and asked for more information on why the prices have increased. He cited the cost to parents when children must have them and to schools that keep EpiPens on hand. The school costs are passed on to taxpayers, he said.

New York Rep. Grace Meng on Tuesday asked the House Oversight and Government Reform Committee to hold a hearing. She is a co-chair of the Congressional Kids Safety Caucus.