DENVER (AP) — Leonard Fournette ran for a career-high 225 yards and Josh Lambo kicked a 33-yard field goal as time expired, sending the Jacksonville Jaguars past the winless Denver Broncos 26-24 Sunday.

The Broncos (0-4) not only were victimized by a last-second field goal for the second time this season, but they blew a 14-point lead at home in a loss for the first time since 2006.

Gardner Minshew II drove the Jaguars, one of four AFC South teams who are 2-2, into field goal range after Joe Flacco’s 8-yard TD throw to Courtland Sutton with 1:38 left gave Denver a 24-23 lead.

Eerily reminiscent of their 16-14 loss to the Bears in Denver two weeks ago, the Broncos helped ignite the winning drive by getting whistled for roughing the passer.

Against Chicago, it was Bradley Chubb’s questionable penalty, which the league admitted was a bad call. Against the Jaguars, it was a flag by Von Miller, who reached up and struck Minshew in his neck just as he released his pass in a chaotic pocket.

Miller’s foul spoiled his big day in which he collected his 99th and 100th career sacks and drew several holding penalties, one of which wiped a Jaguars touchdown off the board.

The 15-yard flag on a 1-yard throw on second down gave Jacksonville a first-and-10 at its 41.

Fournette topped his previous career high of 181 yards on Oct. 8, 2017, at Pittsburgh, and his big run Sunday was an 81-yarder that set up Jacksonville’s go-ahead score.

The Broncos finally ended their sack drought, dropping Minshew five times, but suddenly they couldn’t stop the run.

The result was their first home loss in which they led by 14 or more points since Nov. 19, 2006, when they were beaten by the Chargers 35-27 after jumping out to a 24-7 lead.

Jacksonville hadn’t had a 100-yard rusher in 22 games, the second-longest streak in the NFL behind Philadelphia’s 32-game drought.

The Jaguars also recorded their first takeaway of the season despite missing star cornerback Jalen Ramsey, who was deactivated and missed a game for the first time in his four-year NFL career. He missed practice all week, first with an illness, then a back injury and finally for paternity leave.

Denver led 17-6 and was driving for another score just before halftime when safety Ronnie Harrison intercepted Flacco, who airmailed a pass to Emmanuel Sanders. That set up Lambo’s second field goal, cutting Jacksonville’s deficit to 17-6 at the half.

Coming out of the break, the Jaguars employed a heavy front with 308-pounder Cedric Ogbuehi serving as an eligible receiver and extra blocker for Fournette.

The Jaguars went on a 75-yard, 16-play opening drive that ate up nearly 10½ minutes, which Minshew capped with a 7-yard TD toss to running back Ryquell Armstead after slipping two potential sacks and with Derek Wolfe and Miller bearing down on him.

After Denver went three-and-out, Fournette reeled off his 81-yard run, setting up tight end James O’Shaughnessy’s 18-yard TD grab that put the Jaguars ahead 20-17.

The Jaguars ate up another seven minutes in going 78 yards in 13 plays to push their lead to 23-17 on Lambo’s 34-yarder with 2:54 left.

Rookie tight end Noah Fant scored his first career TD on a 25-yard catch-and-run dumpoff from Flacco, who also hit Sutton for a first-half TD.

INJURIES:

Broncos ILB Josey Jewell aggravated a hamstring injury in the second quarter and was done for the day.

UP NEXT

Jaguars: Visit the Carolina Panthers on Sunday.

Broncos: Visit the Los Angeles Chargers on Sunday.

DETROIT (AP) — Darrel Williams ran for a go-ahead, 1-yard touchdown with 23 seconds left for his second score in the fourth quarter, lifting the Kansas City Chiefs to a 34-30 win over the Detroit Lions.

Detroit drove to the Kansas City 44 on the final drive and Matthew Stafford heaved two passes toward the end zone that were incomplete, ending the game.

The Chiefs (4-0) went ahead for the first time Sunday early in the third quarter when Bashaud Breeland recovered Kerryon Johnson’s fumble and returned it 100 yards, taking advantage of everyone on the field appearing to stop momentarily and the officials not blowing a whistle. The pivotal play stood after review.

The Lions (2-1-1) scored the first 10 points and, after Kansas City pulled into two ties, went back ahead late in the second, third and fourth quarters.

Stafford threw a 6-yard touchdown pass to Kenny Golladay with 2:26 left to give Detroit a 30-27 lead. The call on the field stood after a review, which showed Golladay got both feet in the end zone. Golladay had a touchdown overturned by review early in the third because he appeared to lose control of the football as he hit the turf.

Kansas City started the winning drive on its 21. Patrick Mahomes converted a fourth-and-8 from his 34 with a 15-yard run to help him finish with a career-high 56 yards rushing and he completed just enough passes to set up Williams for a short run to take the lead for good.

Mahomes was 24 of 42 for 315 yards. The reigning MVP had thrown at least two touchdown passes in 14 straight games, one short of the NFL record set by Peyton Manning.

Stafford was 21 of 34 for 291 yards with three touchdowns, including two to Golladay and one to T.J. Hockenson. Stafford’s second touchdown pass of the game — and first to Golladay — put Detroit up 23-20 and followed a fifth fumble in the third quarter. Johnson had 125 yards rushing on 26 carries.

INJURIES

Chiefs: DE Alex Okafor (hip) and LB Damien Wilson (concussion) left in the fourth quarter.

Lions: Hockenson (concussion) was carted off the field in the third quarter and S Quandre Diggs (hamstring) left in the first quarter.

UP NEXT

Chiefs: Host the Indianapolis Colts.

Lions: Bye week.

STILLWATER, Okla. (AP) — Chuba Hubbard ran for 296 yards and a touchdown on just 25 carries, and Oklahoma State shut down No. 24 Kansas State’s own vaunted rushing attack in a weather-delayed 26-13 victory Saturday night.

Hubbard hardly carried at all in the first quarter for the Cowboys (4-1, 1-1 Big 12), who built a 13-0 lead when the game was halted more than an hour in the second quarter due to lightning. But the breakout star finished with runs of 53, 84 and 44 yards in his dominant performance.

Spencer Sanders added 153 yards passing and a touchdown for Oklahoma State. Most of that went to Tylan Wallace, who hauled in eight passes for 145 yards.

Skylar Thompson was 11 of 23 for 118 yards for the Wildcats (3-1, 0-1), who were coming off a bye following their big win at Mississippi State. But any momentum they gained from their foray into SEC country was wiped out by their return to the Big 12.

By the time lightning hit and the officials ordered everyone off the field, the Cowboys had a 208-32 edge in offensive yardage. And when the game resumed, Kansas State kicked a field goal only for Oklahoma State to answer with a touchdown drive to take a 16-3 lead into halftime.

Hubbard added his 84-yard touchdown run in the third quarter before the Wildcats tacked on a field goal by Blake Lynch and a short touchdown run by James Gilbert to make it a game.

Oklahoma State added a field goal in the closing seconds when the outcome was already decided.

TAKEAWAY

Kansas State entered the game 10th in the nation in rushing, averaging 280 yards, but struggled for most of this one. Through the first half, new coach Chris Klieman’s team gained just 18 yards on 13 carries, and had just 68 heading into the final couple minutes of the third quarter. In the end, the Wildcats wound up with 126 yards on 32 carries.

Oklahoma State had issues capitalizing in the red zone in its previous game, a 36-30 loss at No. 11 Texas. And once again, the Cowboys could not punch the ball in from inside the 20. It was a pair of turnovers and a turnover-on-downs against the Longhorns, while it was three field goals against Kansas State. The only difference Saturday night was the outcome.

Kansas State returns home to take on Baylor next Saturday.

Oklahoma State heads to Lubbock next Saturday to face Texas Tech.